Vasopressin hormone receptor density and gene expression in lithium induced polyuria rats.
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Date
2011-10
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Abstract
Lithium, a drug frequently used for treatment of affective disorders, is known to
cause a vasopressin resistant state, leading to polyuria and polydipsia. It has been suggested
that lithium interacts with the renal V2-vasopressin receptor and makes the receptor
dysfunctional. Detailed studies on the influence of lithium on the AVP receptor, however, have
so far been difficult due to the lack of a suitable radioligand with high specific activity and high
affinity. In this study, the effect of Lithium carbonate (20mg/kg i.p) on vasopressin receptor
binding in the kidney and brain and the effect on mRNA expression was determined. The
results of this study suggest that there was significant change in the receptor binding and gene
expression in tissues of polyuria rats as compared to the control rats.
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Keywords
Vasopressin hormone receptor, Gene expression, Lithium, polyuria rats
Citation
Tyagi Manoj G. Vasopressin hormone receptor density and gene expression in lithium induced polyuria rats. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Oct-Dec; 2(4): 81-86.