Biochemical Changes Induced by the Toxicity of Variable Sizes of Silver Nanoparticles.
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Date
2014-12
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Abstract
Background: Silver nanoparticles (SNPs) rapid involvement in industry and
nanomedicine increased human exposure to variable forms of these particles, with
possible potential risk on human health.
Aims: The aim of this study is to investigate the biochemical changes induced by variable
sizes of SNPs toxicity.
Place and Duration of Study: Faculty of Medicine, The University of Jordan and the College of Applied Medical Sciences at Aljouf University, Saudi Arabia, between January
2013 and January 2014.
Study Design: Forty-two male mice were subjected to a daily single dose (1mg/kg body
weight) of SNPs using five different sizes (10 nm, 20 nm, 40 nm, 60 nm and 100 nm) for
35 days.
Methodology: Biochemical changes of the following eleven biochemical tests were
determined: aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase,
triglycerides, total bilirubin, creatinine, total protein, albumin, urea, uric acid and total
cholesterol.
Results: Silver nanoparticles significantly elevated aspartate aminotransferase, alanine
aminotransferase, alkaline phosphatase, triglycerides, total bilirubin and creatinine, with
no significant change in total protein level while albumin and total cholesterol levels were
lowered.
Conclusion: The findings indicate that exposure to SNPs produced significant
biochemical changes that might affect the functions of the vital organs. Moreover, these
alterations were size-dependent with smaller particles (10 nm and 20 nm) induced more
alterations than the larger ones.
Description
Keywords
Silver nanoparticles, AST, ALT, ALP, nanotoxicity
Citation
Jarrar Qais, Battah Abdelkader, Obeidat Fatima, Battah Khairat. Biochemical Changes Induced by the Toxicity of Variable Sizes of Silver Nanoparticles. British Journal of Pharmaceutical Research. 2014 Dec; 4(24): 2670-2678.