Physico-Chemical Evaluation of Guduchyadi Kwatha for Instant Use: An Ayurvedic Herbal Formulation.
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Date
2014-11
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Abstract
Introduction: Kwatha (decoction) preparations are one among commonest practiced
Ayurvedic dosage forms, which are highly effective, but they are to be used when freshly
prepared due to short shelf life (i.e. 1/2- 1 day), and they are often overlooked due to the
preparation method and palatability. In present study, Guduchyadi Kwatha, a known Ayurvedic formulation used in Jwara (~pyrexia), was converted into a different dosage
form for instant use by Rasakriya method (to convert into semi solid state), to make it
easy to dispense, increase the shelf life, make it palatable, for dose fixation, etc.
Aims and Objectives: To evaluate physico-chemical profile of fresh Guduchyadi Kwatha
(GKF) and Guduchyadi Kwatha for instant use (GKI).
Materials and Methods: Five batches of GKI and GKF were prepared and findings were
systematically recorded. Organoleptic evaluation (Hedonic scale method)
Physicochemical parameters (Loss on drying, Ash value, Acid insoluble ash, pH, Total
solid content, Specific gravity, Water and Methanol soluble extractive, solubility and
dissolution rate tests), High performance thin layer chromatography (HPTLC) profile, and
microbial over load were carried out.
Results and Conclusion: Comparative organoleptic screening of GKF and GKI showed
no major differences in color and smell. In GKF, pH value, total solid content, specific
gravity, and surface tension were found as 6.0, 95.14%, 1.009 w/w and 27.19 dynes/cm
respectively. In finished product (GKI), pH value, loss on drying, Ash value, water soluble
and alcohol soluble extractives were obtained as 6.16, 1.93% w/w, 7.90% w/w, 63.69%
w/w and 37.29% w/w respectively. No microbial overload was detected in the sample.
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Keywords
Kwatha, decoction, quality control, HPTLC, hedonic scale method
Citation
Prajapat Rohit, Sharma Rohit, Prajapati P K. Physico-Chemical Evaluation of Guduchyadi Kwatha for Instant Use: An Ayurvedic Herbal Formulation. British Journal of Pharmaceutical Research. 2014 Nov; 4(22): 2599-2613.