Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation.
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Date
2014-11
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Abstract
This study aimed at the investigation of piroxicam-niosomal hydrogel for ocular targeting
to prolong and enhance its local analgesic activity. Various formulations were prepared, characterized and evaluated ex vivo for their transocular permeation using excised cow
cornea. The prepared niosomes had distinct spherical multi-lamellar shape and mean
vesicle size between 1.25±0.81μm and 7.47±0.85μm. Relevant increase in drug EE% was
obtained with increase of cholesterol content and surfactant’s hydrophobicity. Drug
retention in vesicles was significantly (p<0.05) higher at refrigerated condition than that at
the room temperature. Prolonged drug release was achieved with high niosomal
cholesterol content and the mechanism of drug release can be described as Fickian
diffusion. The niosomal hydrogel showed 3.7 Permeability Improvement Ratio comparing
to piroxicam aqueous suspension. The optimized niosomal gel showed prolonged drug
release and enhanced piroxicam ocular bioavailability due to the formation of an
amorphous drug form within the gel.
Description
Keywords
Piroxicam, niosomes, span surfactants, hydrogel, ocular, bioavailability, extended release
Citation
Rasool Bazigha K Abdul, Azeez Oday S, Lootah Hamda A, Abusharbain Iman M, Abu-Alhaj Hiba A, Nessa Fazilatun. Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation. British Journal of Pharmaceutical Research. 2014 Nov; 4(21): 2494-2510.