Phytochemical, Nutrient Composition and Serum Lipid Lowering Effect of Xylopia aethiopica Fruit.
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Date
2014-09
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Abstract
Aims: The present study was carried out to evaluate the effects of Xylopia aethiopica
on serum lipids in fed rats. Also the quantitative phytochemical and nutrient composition was investigated.
Study Design: Quantitative phytochemical, proximate analysis and in vivo effect on
serum lipid profile.
Place and Duration of Study: Department of Biochemistry, College of Natural Sciences,
Michael Okpara University of Agriculture, Umudike Abia State, between June 2013 and
September 2013.
Methodology: The fruit were cut into small piece, dried and ground into powder. The
quantitative phytochemical and proximate nutrient analyses of the powder sample were
determined using standard methods. The serum lipid lowering effects of the powdered
fruit in rats was determined by feeding different groups of rats with graded levels (5, 10,
20 and 50%) of the powdered fruit incorporated in their feed for 21 consecutive days and
the effects on the total cholesterol, triglyceride, LDL-C, and HDL-C were compared with a
negative control.
Results: The fruit sample produced significant (p<0.05) concentration-dependent
decrease in the total serum cholesterol, triglyceride, LDL-C and VLDL-C levels and
increase in serum HDL-C level in fed groups of rats when compared to the control group.
The phytochemical analysis showed that the sample contained tannins (4.96%),
flavonoids (0.81%), saponins (2.93%) and alkaloids (1.24%). The proximate analysis of
the nutrient composition of powdered Xylopia aethiopica sample showed the presence of
moisture, lipid, crude fibre, crude protein, ash and nitrogen free extracts in the following
proportion 6.32, 12.54, 14.51, 0.91, 2.31 and 63.41% respectively.
Conclusion: The fruit sample demonstrated good hypolipidemic effects which may
suggest that the consumption of Xylopia aethiopica fruit may help in the reduction of the
incidence of hyperlipidemia related diseases in patients.
Description
Keywords
Xylopia aethiopica, hypolipidemia, phytochemicals, proximate analysis
Citation
Omeh Yusuf N, Onoja Samuel O, Ezeja Maxwell I, Bassey S, Ogbenta G, Adetayo Ayoade B. Phytochemical, Nutrient Composition and Serum Lipid Lowering Effect of Xylopia aethiopica Fruit. British Journal of Pharmaceutical Research. 2014 Sept; 4(17): 2096-2105.