Effect of Ethanolic Extracts of Lemon Grass and Mango Bark on the Cerebral Astrocytes of Adult Wistar Rats.
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Date
2014-08
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Abstract
Aims: Lemon grass and mango bark serves as one of the medicinal plants used in
Nigeria for the treatment of malaria by traditional herbalists. This study was designed to
assess the effects of ethanolic extract of lemon grass and mango bark on the cerebral
astrocytes of wistar rats.
Place and Duration of Study: Department of Human Anatomy, Faculty of Basic Medical
Sciences, University of Calabar, Calabar, Nigeria between December 2013 and May
2014.
Methodology: Twenty (20) adult wistar rat were divided into four groups, each consisting
of five rats. Group A served as the control that received distilled water, while the
experimental groups B, C and D received 2000mg/kg ethanolic extract of lemon grass,
2000mg/kg ethanolic extract of mango bark, a combination of 1000mg/kg ethanolic extract
of lemon grass and 1000mg/kg ethanolic extract of mango bark orally with the aid of
orogastric tube respectively for two weeks and were sacrificed using chloroform. The
brain of the rats were harvested and preserved using 10% formal saline. Histological
processes were carried out and the tissues were stained using Hortegas. Results: Neurohistological studies carried out revealed hyperplasia of astrocytes in the
treated groups B, C and D animals that received 2000mg/kg of ethanolic extract of lemon
grass, 2000mg/kg of mango bark and combined 1000mg/kg of ethanolic extract of lemon
grass and 1000mg/kg of ethanolic extract of mango bark. There was increased
hyperplasia in group B animals that received 2000mg/kg of the lemon grass extract when
compared with the control and the treated groups C and D.
Conclusion: Thus, ethanolic extract of lemon grass, mango bark and combined extracts
of mango bark and lemon grass has the potential to cause neuronal damage as seen in
the hyperplasia of cerebral cortex astrocytes.
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Keywords
Lemon grass, mango bark, cerebral cortex, astrocytes, neurohistology
Citation
Eluwa M A, Ngwu E I, Asuquo O R, Akpantah A O, Isamoh T E, Ekanem T B. Effect of Ethanolic Extracts of Lemon Grass and Mango Bark on the Cerebral Astrocytes of Adult Wistar Rats. British Journal of Pharmaceutical Research. 2014 Aug; 4(16): 1956-1962.