Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh.
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Date
2014-07
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Abstract
Aims: The crude methanol extract of whole plant of Blumea lacera (Burn.f.) DC. has been
investigated for anti-diarrheal, antimicrobial, anxiolytic, anti-atherothrombosis, membrane
stabilizing and alpha-amylase inhibitory activities.
Place and Duration of Study: The study was carried out in 2013 in the Department of
Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh.
Methodology: Test for anti-diarrheal activity was carried out by castor oil-induced
diarrhea in mice. The preliminary antimicrobial activity was determined by the agar disc
diffusion method. The anxiolytic activity was examined in mice by using the hole board
test and open field test (OFT). The anti-atherothrombosis activity was evaluated using
standard streptokinase. The membrane stabilizing activity was assessed by using
hypotonic solution induced hemolysis of human erythrocyte. The plant extract was also
assessed for anti-diabetic ability using In vitro α-amylase inhibitory potential. The α-
amylase inhibitory activity of B. lacera was measured using the starch-iodine method. Results: The crude extract of B. lacera showed anti-diarrheal activity in dose-dependent
manner. In antimicrobial assay, this extract showed better activity against the tested fungi
compared to the bacteria used in the screening. Significant anxiolytic activity was found
for this plant extract. In the In vitro anti-atherothrombosis test, the extract exhibited
46.17% clot lysis as compared to the standard, streptokinase (81.53%). In membrane
stabilizing activity test, the plant extract at 1.0mg/ml inhibited the heat-induced hemolysis
of RBCs by 52.27% whereas the standard acetyl salicylic acid (ASA) demonstrated
81.72% inhibition of hemolysis. Our results revealed that the extract had dose dependent
prevention of digestion of carbohydrates by inhibiting α-amylase. The ability of B. lacera to
inhibit thermal-and hypotonic-enzyme activity was found to be statistically significant
(p=0.05).
Conclusion: These results demonstrated that B. lacera may be used in pharmaceutical
applications because of its effective pharmacological properties.
Description
Keywords
Blumea lacera, anti-diarrheal, antimicrobial, anxiolytic, anti-atherothrombosis, membrane stabilizing, alpha-amylase
Citation
Khair Abul, Ibrahim Mohammed, Ahsan Qamrul, Homa Zilly, Kuddus Md Ruhul, Rashid Ridwan Bin, Rashid Mohammad Abdur. Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh. British Journal of Pharmaceutical Research. 2014 July; 4(13): 1677-1687.