Anti-inflammatory, Antiarthritic and Antinociceptive Activities of 3,5-Disubstituted Thiazolidine Derivatives.
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Date
2014-04
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Abstract
Aims: The aim of this study was to investigate the anti-inflammatory, antiarthritic and
antinociceptive effects of two thiazolidinedione derivatives: 3-(2-bromo-benzyl)-5-(4-
methylsufonyl-benzylidene)-thiazolidine-2,4-dione (LPSF/GQ-125) and 3-(2,6-difluorobenzyl)-
5-(4-methylsufonyl-benzylidene)-thiazolidine-2,4-dione (LPSF/GQ-192).
Study Design: Study the effects of thiazolidinedione derivatives on the inflammatory
process.
Place and Duration of Study: Department of Antibiotics of the Federal University of
Pernambuco, Brazil, between March 2010 and February 2012.
Methodology: The carrageenan-induced air pouch in mice was performed and cytokine
levels (TNF-α and IL-1β) were determined. Arthritis was induced in female wistar rats by complete Freund's adjuvant (CFA). To determine the antinociceptive activity, acetic acidinduced
nociception and hot plate tests in mice were utilized.
Results: Treatment with the compounds reduced leukocyte migration and the release of
both TNF-α and IL-1β in the air pouch. Both LPSF/GQ-125 and LPSF/GQ-192 reduced
the CFA-induced paw edema and the nociception induced by acetic acid; the hot plate
test, however, showed no antinociceptive activity when compared to the control group.
Conclusion: These results indicate that LPSF/GQ-125 and LPSF/GQ-192 exhibit
promising anti-inflammatory, antinociceptive and antiarthritic activities related to their
ability to inhibit TNF-α and IL-1β production as well as reduction of leukocyte migration.
Description
Keywords
Thiazolidinones, inflammation, air-pouch, arthritis
Citation
Malta Diana Jussara do N, Araújo Larissa Cardoso C, Carrazoni Aline S G, Mota Fernanda Virginia B, da Silva Sandra Cabral, Carmino Maria Andrea de S, Lima Maria do Carmo A, Pitta Ivan da Rocha, da Silva Teresinha Gonçalves. Anti-inflammatory, Antiarthritic and Antinociceptive Activities of 3,5-Disubstituted Thiazolidine Derivatives. British Journal of Pharmaceutical Research. 2014 Apr; 4(8): 992-1003.