Antidepressant-like Activity of Celastrus paniculatus Seed Oil in Mice Subjected to Chronic Unpredictable Mild Stress.
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Date
2014-03
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Abstract
Aims: The present study was done to evaluate the antidepressant-like effect of Celastrus
paniculatus seed oil in Swiss young albino mice subjected to chronic unpredictable mild
stress.
Study Design: Prospective.
Place and Duration of Study: Department of Pharmaceutical Sciences, Guru
Jambheshwar University of Science and Technology, Hisar, Haryana, India, between
August 2012 to February 2013.
Methodology: The behavioral models such as forced swim test (FST) and sucrose
preference test were used to evaluate the effect of seed oil on depression in mice. The oil
(50, 100 and 200 mg/kg, p.o.) and fluoxetine (20 mg/kg, p.o.) per se were administered for
14 successive days to unstressed and stressed mice. The effect of oil on locomotor
activity of mice was also evaluated. In addition, the effects of oil on brain monoamine
oxidase-A, malondialdehyde levels, reduced glutathione and catalase activities; and
plasma corticosterone and nitrite levels were also assessed.
Results: The oil significantly decreased immobility period of both unstressed and
stressed mice in FST as compared to the control. The oil also prevented the stressinduced
decrease in sucrose preference, indicating significant antidepressant-like activity There was no significant effect on locomotor activity of mice by the oil. Antidepressant-like
activity of the oil was comparable to the standard drug, fluoxetine. The oil also significantly
decreased monoamine oxidase-A (MAO-A) activity, malondialdehyde levels in both
unstressed and stressed mice; and significantly prevented stress-induced decrease in
reduced glutathione and catalase activities. It also significantly attenuated stress inducedincrease
in plasma nitrite and corticosterone levels.
Conclusion: Celastrus paniculatus seed oil showed significant antidepressant-like activity
in both unstressed and chronic unpredictable mild stressed mice probably due to inhibition
of MAO-A activity, decrease in plasma nitrite levels; and through scavenging of free
radicals. In addition, the oil also showed antidepressant-like activity in stressed mice
probably through decrease in plasma corticosterone levels.
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Keywords
Celastrus paniculatus, corticosterone, depression, forced swim test, monoamine oxidase, sucrose preference test, chronic unpredictable mild stress
Citation
Valecha Rekha, Dhingra Dinesh. Antidepressant-like Activity of Celastrus paniculatus Seed Oil in Mice Subjected to Chronic Unpredictable Mild Stress. British Journal of Pharmaceutical Research. 2014 Mar; 4(5): 576-593.