Phytochemical Screening and Antipyretic Effect of Curcuma zedoaria Rosc. (Zingiberaceae) Rhizome.
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Date
2014-03
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Abstract
Aims: To investigate the antipyretic effect of ethanol extract of Curcuma zedoaria Rosc.
(Zingiberaceae) rhizome in animal model.
Study Design: Extraction of plant constituents and evaluation of elevated body
temperature lowering activity.
Place and Duration of Study: Department of Pharmacy, North South University, Dhaka
between October 2012 and August 2013.
Methodology: We have performed phytochemical screening and evaluated antipyretic
activity of ethanol extract of the rhizome of Curcuma zedoaria by yeast-induced pyresis
method. Ethanol extract of Curcuma zedoaria rhizome was administered to healthy rats.
Results: The results showed that the ethanol extract of Curcuma zedoaria significantly
reduced yeast-induced elevated body temperature in rats in a dose dependent manner
and the antipyretic effect at a dose of 750 mg/kg was comparable to that of the standard
antipyretic drug paracetamol (10 mg/kg). Phytochemical screening of ethanol extract
showed presence of tannins, flavonoids, saponins, alkaloids, terpinoids, carbohydrates
and steroids as main constituents in Curcuma zedoaria extract some of which may
possess antipyretic activity.
Conclusion: The results justify the traditional use of the ethanol extract of Curcuma
zedoaria in the treatment of fever.
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Keywords
Curcuma zedoaria, phytochemical screening, antipyretic
Citation
Azam Md Golam, Noman Md Shibly, Al-Amin Md Mamun. Phytochemical Screening and Antipyretic Effect of Curcuma zedoaria Rosc. (Zingiberaceae) Rhizome. British Journal of Pharmaceutical Research. 2014 Mar; 4(5): 569-575.