Antibacterial Screening of Some Synthesized Palmitoyl Amino Acids and Their Aromatic Analogues.
Loading...
Date
2014-02
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: The aims of the research were to synthesize, characterize some palmitoyl amino
acids and their aromatic analogues and to screen the synthesized compounds for
possible antibacterial activity
Study Design: Synthesis, characterization and antibacterial screening of palmitoyl amino
acids and their aromatic analogues.
Place and Duration of Study: Department of Pharmaceutical and Medicinal Chemistry/
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy,
Niger Delta University, Wilberforce Island, between September 2012 and January 2013.
Methodology: Palmitoylchloride was condensed with the respective amino acids (glycine,
β-alanine, γ-amino butyric acid) to form the corresponding palmitoyl amino acids. The
opening of the isatoic anhydride ring with the three amino acids and subsequent
condensation with palmitoyl chloride led to the formation of the amino acid benzamides.
The antibacterial screening was carried out using agar well diffusion method. Results: All the synthesized compounds were obtained in good yield and high purity; they
were unequivocally characterized by the combination IR, 1H NMR, 13C NMR and MS. The
compounds were however found to possess no antibacterial activity against the tested
microorganisms
Conclusion: This work has shown that both the straight chain and aromatic analogues of
saturated long chain lipid amides are inactive against the tested strains of microorganism.
Description
Keywords
Lipid amides, palmitoyl glycine, palmitoyl alanine, palmitoyl GABA, benzamides, antibacterial
Citation
Baba Haruna, Usifoh Cyril O, Onanuga Adebola. Antibacterial Screening of Some Synthesized Palmitoyl Amino Acids and Their Aromatic Analogues. British Journal of Pharmaceutical Research. 2014 Feb; 4(4): 513-519.