Superporous Hydrogel Composites of Acrylamide Using Starch-silicone Dioxide Coprecipitate as Composite Agent.
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Date
2014-02
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Abstract
Aim: Present study includes the development and evaluation of superporous hydrogel
composites of acrylamide using starch silicone dioxide coprecipitate (SSC) as composite
agent.
Methodology: Gas blowing method was used for synthesis of superporous hydrogels.
Different ingredients were mixed in specified amount in test tube and foaming agent was
added at last. Simultaneous foaming and gelation lead to formation of porous hydrogel
networks. Effect of different treatments (acetone dehydration and simulated gastric fluid
(SGF) treatment) and drying conditions on the porous structure was evaluated. The
prepared superporous hydrogels were evaluated for density, porosity, equilibrium swelling
ratio, equilibrium swelling time, mechanical strength, scanning electron microscopy
studies. The pure drug (Verapamil Hydrochloride) mixed with Carbopol 934 (1:0.5 and 1:1
ratio) was loaded into the selected batches of SPHC using in situ method of drug loading (drug added directly into the reaction mixture). The in vitro drug release was carried out
using USP II dissolution apparatus.
Results: Acetone dehydrated superporous hydrogel composites were observed as better
floating devices due to least density and maximum porosity values. Maximum swelling
ratio was found in case of oven dried conventional superporous hydrogel and
superporous hydrogel composites with equilibrium swelling time of more than 25 min. On
the other hand, acetone dehydrated SPH showed less equilibrium swelling ratio with
equilibrium swelling time of 5-10 min. Minimum swelling ratio was observed in case of
SGF treated hydrogels with equilibrium swelling time of 15-19 min. Mechanical strength
was improved by addition of starch silicone dioxide coprecipitate as composite agent.
SGF treatment also leads to enhanced mechanical strengthbut compromised swelling
characteristics. SEM images showed uniformity in pore structure in case of acetone
dehydrated hydrogels. Acetone dehydrated SPHC showed sustained drug release
behavior with 71.14% and 57.84% of verapamil released in 12 h in the batches with Drug:
Carbopol 934ratio of (1:0.5 and 1:1) respectively.
Conclusion: Acetone dehydrated SPHC were found to be promising formulations with
sufficient swelling and mechanical properties for achieving sustained drug delivery.
Description
Keywords
Composite agent, gas blowing, starch silicone dioxide coprecipitate, mechanical strength, equilibrium swelling
Citation
Goyal Ashwani, Nagpal Manju, Bhalla Shikha, Dhingra Gitika Arora. Superporous Hydrogel Composites of Acrylamide Using Starch-silicone Dioxide Coprecipitate as Composite Agent. British Journal of Pharmaceutical Research. 2014 Feb; 4(3): 338-351.