Comparative Hepatoprotective Potential of Tinospora cordifolia, Tinospora sinensis and Neem-guduchi.
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Date
2013-10
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Abstract
Aims: Aim of this study was to evaluate the comparative efficacy of Tinospora cordifolia
(Willd.) Miers ex Hook. F., Tinospora sinensis (Lour.) Merrill and T. cordifolia growing on
Neem (Azadirachta indica A. Juss.) called Neem-guduchi.
Study Design: Selected species have been widely used in the traditional medicine
systems in various dosage forms to treat liver disorders. They are of common occurrence
and are being used as substitutes to each other. There is no comparative
hepatoprotection study yet published, therefore, present study has carried out.
Place and Duration of Study: Interactive Research School for Health Affairs, Pune and Amrutvahini College of Pharmacy, Sangamner, between November 2011 and August
2012.
Methodology: Guduchi-Satwa, a well-known dosage form was prepared according to the
traditional procedure. Hepatoprotective potential was assessed using paracetamolinduced
hepatotoxicity model in rats and evaluated by using biochemical parameters viz.
alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase
(ALP) and total bilirubin (BIL).
Results: Both T. cordifolia and T. sinensis Satwa significantly reduced the paracetamol
induced elevated levels of serum ALT, AST, ALP and BIL at dose of 200 mg/kg, i.p. as
compared to Neem-guduchi.
Conclusions: Satwa preparation form of T. sinensis offers exploitable level of
hepatoprotection potential.
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Keywords
Tinospora cordifolia, Tinospora sinensis, Neem-Guduchi, comparative hepatoprotection
Citation
Nagarkar Bhagyashri, Kulkarni Rohan, Bhondave Prashant, Kasote Deepak, Kulkarni Omkar, Harsulkar Abhay, Jagtap Suresh. Comparative Hepatoprotective Potential of Tinospora cordifolia, Tinospora sinensis and Neem-guduchi. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 906-916.