Analgesic, Anti-Inflammatory and Antipyretic Effect of Mentha spicata (Spearmint).
Loading...
Date
2013-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aim: Mentha spicata (L.) is popularly used as herbal remedy for various ailments. But the
scientific basis for its medicinal use especially in pain and inflammation remains unknown.
Therefore, the present study was aimed to investigate the analgesic, anti-inflammatory
and antipyretic effects of whole plant of Mentha spicata in laboratory animals.
Materials and Method: The methanol extract of Mentha spicata (MEMS) was used to
investigate the acute effect on analgesia by Hot-plate test and acetic acid induced writhing
method (By acetic acid) in mice and on inflammation in rats by carrageen induced paw
edema method. Subcutaneous injection of 20% aqueous suspension of Brewer’s yeast in
wistar rats leads to pyrexia.
Results: The extract showed a significant (p<0.001) dose dependent increase in reaction
time in mice in the hot-plate test at the doses of 250 mg/kg and 500 mg/kg body weight.
The extract showed a significant (p<0.05) dose dependent increase in reaction time in
mice in writhing method at the doses of 250 and 500 mg/kg body weight. The extract also
exhibited promising anti-inflammatory effect as demonstrated by statistically significant
(p<0.05) inhibition of paw volume by 42.58% at the dose of 250 mg/kg body weight and 45.10% at the dose of 500 mg/kg body weight at the sixth hour of study. Intraperitoneal
administration of MEMS showed dose dependent decrease in body temperature in
brewer’s yeast induced hyperthermia in rats at both doses. However, MEMS significantly
decreased body temperature (p<0.05) at 500mg/kg compared to control.
Conclusion: This study suggests that the methanol extract of Mentha spicata have
analgesic, anti-inflammatory and antipyretic activity in a dose dependent manner which
supports its use as an analgesic, anti-inflammatory and antipyretic drug in folk medicine.
Description
Keywords
Analgesic, antipyretic, anti-inflammatory, Mentha spicata
Citation
Yousuf Patwary Md Hajjaj, Noba Nusrat Yousuf, Shohel Mohammad, Bhattacherjee Rajib, Das Biplab Kumar. Analgesic, Anti-Inflammatory and Antipyretic Effect of Mentha spicata (Spearmint). British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 854-864.