Gastroprotective Activity of Methanol Leaves Extract of Barleria prionitis Linn. on Ethanol and Indomethacin Induced Ulcer in Rats.
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Date
2013-10
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Abstract
Aims: Barleria prionitis L. (Family Acanthaceae) is a medicinal plant found road side in
India and whole plant or its various parts like leaves, root, bark, stem and flowers are
used traditionally for various treatments like toothache, inflammation, boils, glandular
swellings and ulcer. Leaf juice is useful in gastric ulcer. Here, we attempt to prove the use
of this plant as gastroprotective agent.
Study Design: This study was conducted to evaluate the antiulcer activity of methanol
extract obtained from the leaves of Barleria prionitis Linn.
Place and Duration of Study: The experiments were conducted at Pharmacology lab of
Institute of Pharmaceutical Sciences, Kurukshetra University during the period of July
2012 to December 2012.
Material and Methods: Antiulcer activity was performed using the protocols of ulcer
induced by ethanol and indomethacin at two different doses (250 and 500mg/kg).
Parameters like volume of gastric juice, pH, free acidity, total acidity, aspartate amino
transferase (AST) and alanine amino transferase (ALT) were also determined in ethanol
induced ulcer model. Results: The reduction in ulcer index in Barleria prionitis treated animals was found to be
statistically significant (P=.05), when compared with control groups in both the models.
Significant changes were observed in total acidity only at dose 500mg/kg only and
changes were significant in AST, ALT levels at both the doses. Other parameters showed
non-significant results.
Conclusion: The results of the present study show that the methanolic extract of Barleria
prionitis L. possess antiulcer activity. This work supports the traditional use of this plant in
treating gastric ulcer.
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Keywords
Barleria prionitis, gastroprotective activity, ulcer index, methanol extract, ethanol
Citation
Manjusha, Kumar Vipin, Singh Surender. Gastroprotective Activity of Methanol Leaves Extract of Barleria prionitis Linn. on Ethanol and Indomethacin Induced Ulcer in Rats. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 817-829.