Preparation and Characterization of Mucoadhesive Buccal Film for Delivery of Meloxicam.
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Date
2013-10
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Abstract
Aims: Preparation of mucoadhesive buccal films able to deliver the meloxicam drug to the
site of application through oral mucosal tissues. This dosage form is advantageous due to
absence the problems of the ordinary dosage forms.
Study Design: In this research, it was prepared a lot of formulations from different
polymers and plasticizers to select the best one which has the optimum and required
characteristics.
Place and Duration of Study: Department of Pharmaceutics, Faculty of Pharmacy, Suez
Canal University and Misr International University, Egypt, between July 2009 and July
2012.
Methodology: There are different polymers used in preparation of the films which are
hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose,
pectin and polyvinyl alcohol. Also, the plasticizers used are glycerin, propylene glycol and
polyethylene glycol. The film was prepared by solvent casting technique. Firstly, the
calibration curve of meloxicam was carried out. Then, the properties of the formulations were examined through some experiments which are determination of drug content, study
of efficacy of mucoadhesion, in-vitro drug release studies and differential scanning
calorimetry.
Results: It was found that the formula containing polyvinyl alcohol 2% (w/w) and
propylene glycol 20% from the weight of the polymer has ideal characteristics. Results
showed that this formula has optimum drug content, acceptable mucoadhesion and fast
drug release with compatibility between drug and excipents.
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Keywords
Meloxicam, mucoadhesion, in-vitro release, differential scanning calorimetry
Citation
Gardouh A R, Ghorab M M, Badawy S S, Gales R B. Preparation and Characterization of Mucoadhesive Buccal Film for Delivery of Meloxicam. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 743-766.