Antioxidant and Antitumor Activity of Plumeria acuminata in Ehrlich Ascites Carcinoma Bearing Swiss Albino Mice.
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Date
2013-10
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Abstract
Aim: This study was designed to determine the antitumor and antioxidant properties of
crude methanol extract from the leaves of Plumeria acuminata (Apocynaceae) (MEPA)
against Ehrlich Ascites Carcinoma (EAC) bearing Swiss albino mice.
Study Design: Study design is methodology, mentioned below.
Place and Duration of Study: Division of Pharmacology, Department of Pharmaceutical
Technology, Jadavpur University, Jadavpur, Kolkata, India between 2006 and 2007.
Methodology: The extract was administered at the doses of 100, 250 and 500 mg/kg per
day for 14 days, after 24 hr of tumor inoculation. After the administration of the last dose
followed by 18 hr fasting, mice were then sacrificed for observation of antitumor activity.
The effect of MEPA on the growth of transplantable murine tumor, life span of EAC
bearing host, viable and non-viable cell count, packed cell volume, hematological profile
and biochemical parameters such as lipid peroxidation (LPO), reduced glutathione
content (GSH), superoxide dismutase (SOD) and catalase (CAT) activities were estimated.
Results: MEPA caused significant (P<0.01) decrease in tumor volume, packed cell
volume and viable count; and it prolonged the life span of EAC-tumor bearing mice.
Hematological studies reveal that the Hb content and RBC count were decreased in EAC
treated mice, whereas the restoration to near normal levels was observed in extract
treated animals. MEPA significantly (P<0.05) decreased the levels of LPO and
significantly increased the levels of GSH, SOD and CAT. Moreover the MEPA was found
to be devoid of conspicuous short-term toxicity in the mice when administered daily for 14
days at the doses of 100, 250 and 500 mg/kg
Conclusion: The results suggested that the methanol extract of Plumeria acuminata
leaves exhibited antitumor effect by modulating lipid peroxidation and augmenting
antioxidant defense system in EAC bearing Swiss albino mice.
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Keywords
Plumeria acuminate, ehrlisch ascites carcinoma, hematological parameters, antioxidant activity
Citation
Periyasamy Gomathi, Gupta Malaya, Mazumder Upal Kanti, Gebrelibanos Mebrahtom, Sintayehu Biruk. Antioxidant and Antitumor Activity of Plumeria acuminata in Ehrlich Ascites Carcinoma Bearing Swiss Albino Mice. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 671-685.