Chronic Anti-Inflammatory Activity of Ethanolic Extract of Leaves of Clerodendrum viscosum by Carrageenin Induced Paw Oedema in Wistar Albino Rats.
Loading...
Date
2013-10
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: The aim of the study was to investigate chronic anti-inflammatory activity of
ethanolic extract of the leaves of Clerodendrum viscosum (EELCV) by carrageenin
induced paw oedema in Wistar albino rats.
Study Design: Prospective.
Place and Duration of Study: Dept of Pharmacology, Yenepoya Medical College,
Yenepoya University, Derlakatte, Mangalore 575018, Karnataka, India. June 2010-August
2010.
Methodology: Dried powdered leaves of Clerodendrum viscosum were subjected to
Soxhlet extraction by using 90 % ethanol. Based on acute oral toxicity study according to
Organization for Economic Cooperation and Development (OECD) guidelines no. 423,
three doses of the test drug was selected (75, 150 & 300 mg/kg) for rats, and were
subjected to screening for anti-inflammatory activity.
Results: Oral administration of EELCV at doses of 150 mg/kg (P = .01) and 300mg/kg (P
= .05) has shown significant anti-inflammatory activity by carrageenin induced paw
oedema in Wistar albino rats compared to control. A significant inhibition of oedema formation was also observed at 4th hour.
Conclusion: Administration of EELCV orally at the doses of 150 mg/kg (P = .01) and
300mg/kg (P = .05) showed significant anti-inflammatory activity by carrageenin induced
paw oedema in Wistar Albino rats. The percentage inhibition of the oedema at 3rd hour
was 63.75 % for the dose of 150 mg/kg and 46.30 % for the dose of 300 mg/kg. A
significant inhibition was also observed at 4th hour.
Description
Keywords
Anti-inflammatory activity, clerodendrum viscosum, carrageenin, indomethacin
Citation
Chandrashekar R, Rao S N. Chronic Anti-Inflammatory Activity of Ethanolic Extract of Leaves of Clerodendrum viscosum by Carrageenin Induced Paw Oedema in Wistar Albino Rats. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 579-586.