Free Radical Scavenging Activities of Nyctanthes arbor-tristis. L on Adjuvant Induced Arthritis in Rats.
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Date
2013-10
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Abstract
Aims: The present study was undertaken to explore in vivo antioxidant potential of
ethanol extracts of Nyctanthes arbor-tristis leaf and stem in adjuvant induced arthritic rats.
Methodology: Arthritis induced rats were administered with extract of Nyctanthes arbortristis
leaf and stem. (150 mg/kg body Weight/rat/day for 30 days.
Results: A significant decrease in paw edema was observed following oral administration
of the leaf and stem extracts. A significant (p<0.05) increase in the level of tissue TBARS,
GPx and catalase was seen in arthritis induced rats (group II) and NAT treated rats (group
III and group IV) showed a significant decrease in lipid peroxides, GPx and catalase level
to near normalcy. The activity of total tissue SOD was found significantly (p<0.05) low in
arthritis induced rats (group II) while a substantial increase in the activity to near normal
level was noticed in NAT administered rats. The alterations in hematological and other
biochemical parameters were restored to near normal levels after a treatment period of 30
days. The structural changes of the tissues shows the therapeutic ability of Nyctanthes
arbor-tristis stem and leaf in experimental animals which were further evidenced by histological observations made on the hind limb tissue.
Conclusion: As Nyctanthes arbor-tristis is of natural origin, it is a safe and effective
intervention for free radical mediated diseases.
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Keywords
Anti-inflammatory, Arthritis, In vivo antioxidant, lipid peroxidation, Superoxide dismutase
Citation
Thomas Smeera, Nirmala J Grace, Narendhirakannan R T. Free Radical Scavenging Activities of Nyctanthes arbor-tristis. L on Adjuvant Induced Arthritis in Rats. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 536-547.