Influence of Sodium CMC and HPMC on the Physical Characteristics of Ofloxacin Floating Matrix Tablets.
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Date
2013-07
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Abstract
Aims: Sustained release floating drug delivery systems or gastro retentive drug delivery
systems enables prolonged and continuous input of drug to the upper part of
gastrointestinal tract and improves the bioavailability of medication. A new strategy is
proposed for the development of floating drug delivery systems of Fluoroquinolone
antibiotic, Ofloxacin, a potent moiety for treating UTI’s.
Methodology: Various rate retarding polymers like HPMC K4M, HPMC 5 cps and
swelling agent as Sodium carboxymethyl cellulose in different proportions were tried and
optimized to achieve the drug release for 8 hr. All the formulations were evaluated for
floating properties, swelling characteristics and in vitro drug release studies. The in vitro
drug release was found to be matrix diffusion controlled. Optimized formulation was
subjected to intermediate stability studies at various combinations of temperature and
humidity according to ICH guidelines.
Results: Lower hardness and higher thickness decreased the floating lag time and
increased floating duration. Based on drug release studies, formulation F5 was optimized
as the best formulation because it released about 89.27 ±2.6% of the drug at the end of 8 hr while other formulations released not more than 80 ±2.2%. This may be due to high
NaCMC content which might have caused excessive channeling, thereby giving a burst
release. Optimized formulation F5 was found to follow zero order kinetics with r2 value of
0.993.
Conclusion: In conclusion we have been proved that HPMC K4M has retarded the drug
release, while HPMC 5cps has facilitated high buoyancy time for the tablets. NaCMC has
influenced as channeling agent. Formulation F5 was optimized for its long buoyancy time,
prolonged duration of drug release, zero order and diffusion controlled drug release
kinetics which can assure 100% bioavailability.
Description
Keywords
Floating drug delivery, diffusion controlled, HPMC, Sodium CMC, ofloxacin
Citation
Hwisa Nagiat T, Chandu Babu Rao, Katakam Prakash, Dasari Varun. Influence of Sodium CMC and HPMC on the Physical Characteristics of Ofloxacin Floating Matrix Tablets. British Journal of Pharmaceutical Research. 2013 July; 3(3): 508-522.