Regulated Effects of Capsicum frutescens Supplemented Diet (C.F.S.D) on Fasting Blood Glucose Level, Biochemical Parameters and Body Weight in Alloxan Induced Diabetic Wistar Rats.
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Date
2013-07
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Abstract
Aim of the Study: This study investigates the effects of Capsicum frutescens
supplemented diet (C.F.S.D) on fasting blood glucose level, biochemical parameters and
body weight in alloxan induced diabetic Wistar rats.
Experimental Design: 130 – 150g healthy forty male Wistar rats were divided into four
groups as following; Group 1 served as a normal control and received normal feed-.
Group 2 (Diabetic control) received normal feed-. Group 3 (Diabetic test 1) received
normal feed + 1g Capsicum frutescens.-. Group 4 (Diabetic test 2) received normal feed +
2g Capsicum frutescens.
Place and Duration of Study: This study was carried out in the department of
Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka and the feeding lasted for three weeks. At the end of the experiments, the animals were sacrificed,
blood samples were collected and then the serum was further subjected to biochemical
analysis using biochemical analyzer (Reflotron Plus).
Results: AST, ALT, ALP, GGT, Creatinine, Uric acid, total cholesterol and fasting blood
sugar level in serum were increased however the high density lipoprotein cholesterol
(HDL-c) of serum was decreased in diabetic control (group 2), compared with non-diabetic
control (group 1). The administered Capsicum frutescens in the diet at 1g and 2g doses
significantly reduced the fasting blood glucose level as well as the serum level of AST,
ALT, ALP, GGT, Creatinine, Uric acid, total cholesterol, compared with diabetic control.
Serum HDL was also significantly increased when compared with diabetic control P<0.05.
Decrease in body weight in diabetic control group and increased in body weight of 1gand
2g Capsicum frutescens supplemented diet groups were also observed.
Conclusion: The observed improvement in the biochemical parameters, blood glucose
levels and body weight of alloxan induced diabetic Wistar rats by 1g and 2g Capsicum
frutescens supplemented diet suggests Capsicum frutescens to possess, cardioprotective
and anti-diabetic properties.
Recommendation: The incorporation of Capsicum frutescens as spice in the diet of
individuals who are diabetic, hypertensive and obese, is worthy of recommendation.
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Keywords
Capsicum frutescens, fasting blood glucose, liver enzymes, capsaicin, thermogenesis
Citation
Anthony Ojieh E, Ese Adegor C, Lawrence Ewhre O. Regulated Effects of Capsicum frutescens Supplemented Diet (C.F.S.D) on Fasting Blood Glucose Level, Biochemical Parameters and Body Weight in Alloxan Induced Diabetic Wistar Rats. British Journal of Pharmaceutical Research. 2013 July; 3(3): 496-507.