Seroprevalence of Anti-Human Metapneumovirus Antibodies in Hospitalized Children in Suleimani City/Iraq.
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Date
2014-12
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Abstract
Background: Human Metapneumovirus (hMPV) is an important respiratory viral pathogen
among children, and it is one of the causes of pediatric hospital admissions due to acute
respiratory tract infections.
Objective: This study was done to predict the seroprevalence of anti-hMPV antibodies
among hospitalized children presenting with acute respiratory tract infections in Suleimani
Governorate, Kurdistan Region/Iraq.
Place and Duration: This study was done at the department of microbiology, school of
medicine, suleimani University, between April 2011 and March 2012.
Methods: Indirect immunofluorescent assay (IIFA) was performed to detect serum antihMPV
antibodies (IgM and IgG antibodies) from three hundred hospitalized children less
than 5 years old with acute respiratory tract infections.
Results: IgM anti-hMPV antibodies were positive in thirty six (12%) out of three hundred
children. The highest seroprevalence was found in the age group <1 year old, while the lowest in the age group 4 to <5 years old. No significant gender difference was found
among seropositive children. The IgM anti – hMPV seropositive children were suffering
from pneumonia, bronchiolitis, or other less severe acute respiratory tract infections like
acute bronchitis and croup in frequencies of sixteen (44%), 10 (28%), and 10 (28%). The
IgG anti-hMPV antibodies were positive in two hundred and twenty five (75%) out of the
three hundred children, and there was a gradual increase in percentage of seropositivity
with increasing age.
Conclusion: hMPV is an important viral respiratory pathogen among hospitalized children
in Suleimani Governorate/Kurdistan/Iraq, and most of the children had experienced hMPV
infection by the age of five years.
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Hospitalized children, indirect immunofluorescence assay, human metapneumovirus, acute respiratory tract infection
Citation
Aziz Tariq A G, Salmo Nabil, Bayati Ali H. Seroprevalence of Anti-Human Metapneumovirus Antibodies in Hospitalized Children in Suleimani City/Iraq. British Microbiology Research Journal. 2014 Dec; 4(12): 1325-1334.