Community-Associated and Health care- Associated Methicillin-Resistant Staphylococcus aureus in Children: A Microbiological and Epidemiological Study.
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Date
2014-11
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Abstract
Aims: Novel methicillin-resistant Staphylococcus aureus have been causing infections in
the community and are now invading hospitals. In this study we aimed to determine, using
epidemiological and microbiological parameters, the characteristics of circulating S.
aureus clinical isolates.
Methods: From July 2009 to April 2012, S. aureus isolates from children hospitalized in
Santa Casa de São Paulo, a tertiary care-center in São Paulo, Brazil, were included. All
isolates grew in cultures from sterile sites and we included only one isolate per patient.
Results: Fifty-five isolates were included during the study period, 47 from blood, six from
abscesses, one from pleural fluid and one from spinal fluid. Among these isolates, 34
were methicillin susceptible S. aureus (MSSA) and 21 were methicillin-resistant S. aureus
(MRSA). Eleven patients were excluded (5 MSSA and 6 MRSA) because clinical charts
were not available for review, reducing the total to 29 MSSA and 15 MRSA isolates. After
searching for risk factor for healthcare-associated infections, 11 of the 15 MRSA isolates
were epidemiologically considered health care-associated MRSA (HCA-MRSA) and 4 community-associated MRSA (CA-MRSA). Using the microbiological classification
(multiresistance), five were considered as HCA-MRSA and 10 were CA-MRSA.
Interestingly, of the 11 isolates considered as epidemiological HCA-MRSA (presence of
any risk factor), six had a microbiological profile (non-multiresistant) consistent with CAMRSA
circulating clones.
Conclusion: Our results clearly show that the boundaries between CA-MRSA and HCAare
increasingly difficult to determine.
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Keywords
Staphylococcus aureus, MRSA, antimicrobiotic resistance, oxacillin
Citation
Erthal Ana Luísa N, Alves Amanda M, Pereira Maria Fernanda B, Mimica Marcelo J. Community-Associated and Health care- Associated Methicillin-Resistant Staphylococcus aureus in Children: A Microbiological and Epidemiological Study. British Microbiology Research Journal. 2014 Nov; 4(11): 1262-1266.