Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines.
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Date
2013-01
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Abstract
Aims: To investigate the cytotoxic activity of rhoifolin against different cancer cell lines.
Study Design: Isolation, identification and cytotoxic activity evaluation.
Place and Duration of Study: Faculty of Pharmacy, Ain Shams University and Al-Azhar
University, between October, 2010 and January, 2011.
Methodology: Rhoifolin, Apigenin 7-O-β neohesperidoside was isolated in a copious
amount from the leaves of Chorisia crispiflora (Bombaceae). Its identity was
unambiguously confirmed via different spectroscopic methods (UV, 1HNMR, 13CNMR and
HMBC) and viability assay test was used to evaluate its cytotoxic activity.
Results: It exhibited potent anticancer activities, nearly similar to that of vinblastine, when
evaluated against human epidermoid larynex (Hep 2) and human cervical (HeLa)
carcinoma cell lines. Promising activities were also obtained against hepatocellular (Hep
G2), colon (HCT-116) and fetal human lung fibroblast (MRC-5) carcinoma cell lines. A
unique effect of rhoifolin was in having no cytotoxic activity against healthy normal cells
(Vero cells) which indicates a high selectivity of this compound.
Conclusion: The findings of this study showed that rhoifolin could be used as an ideal
anticancer agent. It discriminates between cancerous and non cancerous cell as it kills
only the former one. So the side effects which may appear during chemotherapy could be
overcome.
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Keywords
Roifolin, Chorisia crispiflora, Bombaceae, spectroscopic methods, cytotoxic, activity
Citation
Gawde S R, Shetty Y C, Merchant S, Kulkarni U J, Nadkar M Y. Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines. British Journal of Pharmaceutical Research. 2013 Jan-Mar; 3(1): 46-53.