Evaluation of Serum and Salivary IgG in Head and Neck Squamous Cell Carcinoma.
Loading...
Date
2013-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: To evaluate salivary and serum IgG levels in patients with head and neck
squamous cell carcinoma (HNSCC) and healthy control subjects and to assess the effect
of treatment on IgG levels.
Study Design: A cross sectional study.
Place and Duration of Study: Department of Oral Pathology and Department of
Radiotherapy, University College Hospital, Ibadan, Nigeria between January 2010 and
December 2010.
Methodology: Seventy eight subjects comprising 30 patients with untreated HNSCC, 18
patients with HNSCC receiving treatment and 30 healthy, age and gender-matched
individuals were included. Serum and salivary samples from the participants were
analysed for total IgG using ELISA technique.
Results: The mean serum IgG in untreated and treated HNSCC patients was
significantly lower compared with healthy controls (P=.001), while mean salivary IgG was significantly elevated (P=.001) in untreated HNSCC patients compared with treated and
healthy controls. There was no significant correlation between serum and salivary IgG
levels.
Conclusion: In patients with head and neck squamous cell carcinoma, serum IgG was
reduced while salivary IgG was elevated compared with healthy controls. Our finding
suggests differential roles of immunoglobulin G in serum and saliva of patients with head
and neck squamous cell carcinoma. Hence, salivary IgG may be a useful biomarker in
patients with head and neck squamous cell carcinoma, while serum IgG levels may be
useful in monitoring treatment in these individuals.
Description
Keywords
Immunoglobulin G, head and neck squamous cell carcinoma, serum, saliva
Citation
Lasisi T J, Abdus-Salam A, Lasisi O A, Akang E E U. Evaluation of Serum and Salivary IgG in Head and Neck Squamous Cell Carcinoma. British Journal of Medicine and Medical Research. 2013 Oct-Dec; 3(4): 2269-2275.