Nodding Syndrome (NS) in Northern Uganda: A Probable Metabolic Disorder.
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Date
2013-10
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Abstract
Aims: To conduct an epidemiological study to establish the association between
malnutrition, metabolic disorder and Onchocerciasis to Nodding Syndrome (NS) in
Northern Uganda.
Study Design: Case-control study design.
Place and Duration of Study: Odek and Atiak sub counties in Gulu and Amuru districts
between 10th to 20th June 2012.
Methodology: We recruited consecutively 101 children with probable NS in the 2 sub
counties in Gulu and Amuru districts. Controls were from the same population but
without symptoms of NS and were matched by age, sex and residents. History and
physical examinations were conducted; anthropometry, blood samples and skin snips were obtained from cases and controls. Researchers were pediatricians, psychiatrists,
nurses, laboratory scientists and epidemiologists. The research proposal was approved
by the Ministry of Health and the IRB of Gulu University.
Results: There was a statistically significant association between NS with malnutrition
(t=0.142; p=0.044), Onchocerciasis (Χ
2 = 152.74, p<0.001; OR 7.025 95% CI 3.891,
12.682) and High Anion Gap (Χ
2=146.752, p<0.001; OR 6.313 95%CI 4.027, 9.895).
Conclusion: Nodding syndrome is associated with metabolic disorder in young children
who are malnourished and infected with Onchocerciasis.
Description
Keywords
Nodding syndrome, Onchocerciasis, malnutrition, metabolic disorder, Gulu, Northern Uganda
Citation
Lagoro Kitara David, Deogratius Mwaka Amos, Arony Anywar Denis, Gilbert Uwonda, Bernard Abwang, Edward Kigonya. Nodding Syndrome (NS) in Northern Uganda: A Probable Metabolic Disorder. British Journal of Medicine and Medical Research. 2013 Oct-Dec; 3(4): 2054-2068.