The Effect of Atorvastatin (Lipitor) on the Duration of Survival of Allogeneic Skin Graft and the Growth of B16F10 Melanoma Cells in Mice.
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Date
2013-10
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Abstract
Aims: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose
of atorvastatin (AS) on skin allograft survival and on tumor growth in mice.
Study Design: Experimental Study.
Place and Duration of Study: Department of Experimental Pathology, Immunology and
Microbiology, Faculty of Medicine, American University of Beirut; 2011-2012.
Methodology: BALB/c mice were transplanted with skin allografts from C57BL/6 mice
and given either AS alone or in combination with immunosuppressive agents. Average
survival days of skin allografts were recorded and serum levels of interleukin-1β (IL-1β)
and interferon-γ (IFN-γ) were quantified. BALB/c mice and C57BL/6 mice were
challenged intraperitoneally with B16F10 melanoma cancer cells (cancer cell line
syngeneic to C57BL/6 mice) and were then treated with AS. They were observed regularly for tumor growth.
Results: The results indicated that in transplant mice AS given alone or in combination
with immunosuppressive agents prolonged allograft survival time through noncholesterol
lowering mechanisms in spite of a non-significant change in serum cytokine
levels. Furthermore, AS treatment enhanced tumor growth in C57BL/6 mice and
promoted tumor growth in BALB/C mice.
Conclusion: It can be speculated that AS down expresses TLR and modifies MHC
presentation resulting in hindering the generation of an innate and adaptive immune
response.
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Keywords
mmunosuppression, skin transplantation, cancer, statins, cytokines
Citation
Zeidan Nabil, El-Rami Fadi, Al-Akl Nayla S, Abdelnoor Alexander M. The Effect of Atorvastatin (Lipitor) on the Duration of Survival of Allogeneic Skin Graft and the Growth of B16F10 Melanoma Cells in Mice. British Journal of Medicine and Medical Research. 2013 Oct-Dec; 3(4): 1938-1951.