Prevalence of Human Papilloma Virus DNA in HIV Positive Women in Lagos University Teaching Hospital (LUTH) Lagos, Nigeria.
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Date
2013-07
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Abstract
Introduction: HIV-infected women have a high prevalence of Human Papilloma virus
(HPV) infection and are more likely to be infected with high risk genotypes with the potential
of progressing to cervical cancer. There is paucity of data regarding the prevalence of
sexually transmitted HPV infection among HIV positive women in Nigeria.
Aims: The objective of this cross-sectional prospective study was to determine the
prevalence of high risk HPV among HIV positive and negative women in LUTH, Lagos,
Nigeria and to relate HPV genotypes in the study population to commercially available HPV
vaccine types that would be or not be appropriate for implementation of vaccination
programs in Lagos State.
Place and Duration of Study: AIDS Prevention Initiative In Nigeria (APIN) clinic as well as
the Gynecologic outpatient clinic of LUTH, Lagos between August 2011 and August 2012.
Methodology: A combination of PCR and flow through hybridization method was used in
the genotyping of HPV from samples obtained from 98 HIV positive and 97 HIV negative
women. Data was analyzed using Epi info 3.5.6. Non parametric variables were compared with chi-square or Fisher exact test as appropriate. The differences in mean for parametric
variables were compared using student T test. P value <0.05 were considered significant.
Results: The prevalence of HPV among HIV positive women was 44.9% while the
prevalence of high risk types was 37.5%. The commonest high risk types seen were types
31, 52, 53 and 35. The prevalence of HPV among the HIV negative women was 11%. The
commonest high risk types seen were types 18, 16, 52 and 56.
Conclusion: In view of the high prevalence and diversity of HPV genotypes among the HIV
positive women, adequate screening protocols should be put in place for screening this
category of women. Studies should also be carried out to determine the efficacy of existent
HPV vaccines on this group of patients.
Description
Keywords
Prevalence, HPV genotypes, HIV positive women, Lagos
Citation
Nweke I G, Banjo A A F, Abdulkareem F B, Nwadike V U. Prevalence of Human Papilloma Virus DNA in HIV Positive Women in Lagos University Teaching Hospital (LUTH) Lagos, Nigeria. British Microbiology Research Journal. 2013 July; 3(3): 400-413.