Comparative Effect of Type 1 and Type 2 Diabetes Mellitus on Vascular Responses of Rat Thoracic Aorta to Potassium Ion Channel Openers.
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Date
2013-07
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Abstract
Background: Diabetes mellitus is associated with many cardiovascular dysfunction and
impairment of potassium channel function.
Aim: We compared the vascular reactivity in aorta from streptozotocin-induced and
Goto-Kakizaki (GK) diabetic rats to potassium channel openers.
Methodology: Diabetes mellitus (DM) was induced in Sprague Dawley rats by
intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg body weight. After four
weeks of DM, vascular reactivity of the aortic rings from STZ-induced Sprague Dawley
and age-matched GK and control rats to phenylephrine, acetylcholine, levcromakalim
and naringenin was studied using standard organ bath procedure.
Results: The phenylephrine-induced contraction was significantly (P<0.05) increased in STZ-diabetic aortic rings [2.03 ±0.07 g] when compared with GK rats [1.47±0.14 g] and
STZ-control [1.42±0.21 g]. Maximal relaxation and potency to acetylcholine,
levcromakalim and (+/-)-naringenin were significantly (P<0.05) decreased in STZdiabetic
aorta when compared with GK-diabetic and control groups.
Conclusion: The phenylephrine-induced contraction, endothelium-dependent relaxation,
KATP - and (+/-)-naringenin-induced vasorelaxation are not altered in the early stages of
Type 2 diabetes whereas there is exaggerated contractile response and a relaxant
dysfunction involving the endothelium, KATP in Type 1 diabetes mellitus.
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Keywords
Acetylcholine, aorta, Gotto Kakizaki rat, naringenin, potassium channel openers, streptozotocin, vasoconstriction
Citation
Owu Daniel U, Orie Nelson N, Nwokocha Chukwuemeka R, Clapp Lucie H, Osim Eme E. Comparative Effect of Type 1 and Type 2 Diabetes Mellitus on Vascular Responses of Rat Thoracic Aorta to Potassium Ion Channel Openers. British Journal of Medicine and Medical Research. 2013 Jul-Sep; 3(3): 748-759.