Uremic Encephalopathy with Basal Ganglia Lesions in a Diabetic Predialysis Patient.
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Date
2013-04
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Abstract
Syndromes associated with acute bilateral lesions of the basal ganglia in diabetic
uremic patients are uncommon, and usually have reversible clinical and imaging
findings. Such syndromes are seen almost exclusively in patients with diabetes mellitus
and renal failure. Previously reported cases have described diabetic men with uremia
on dialysis.
Here, we report a case of uremic encephalopathy with lesions of the basal ganglia in a
diabetic predialysis patient. A 44-year-old man with uremic encephalopathy presented
with dysarthria, chorea, and right upper extremity paresthesia. Magnetic resonance
imaging of the brain showed classic findings of hyper intensity in the bilateral basal
ganglia. The patient had no family history of psychiatric or neurological disease.
Laboratory findings revealed elevated levels of blood urea nitrogen, creatinine, and
glucose. Haloperidol and ropinirole therapy was continued, resulting in significant
improvement without dialysis. The patient recovered from his episode without apparent
sequelae.
Description
Keywords
Diabetes mellitus, uremic encephalopathy, basal ganglia, predialysis
Citation
Kim Ye Na, Shin Ho Sik, Jung Yeon Soon, Rim Hark. Uremic Encephalopathy with Basal Ganglia Lesions in a Diabetic Predialysis Patient. British Journal of Medicine and Medical Research. 2013 Apr-Jun; 3(2): 249-254.