Association of Polymorphisms in DAZL Gene with Male Infertility.
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Date
2013-01
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Abstract
Objectives: To investigate the association between A260G (Thr12Ala) and A386G
(Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene
(DAZL) and infertility in Jordanian males.
Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile
subjects were recruited in the study. DAZL SNPs were genotyped using polymerase
chain reaction-restriction fragment length polymorphisms (PCR-RFLP).
Results: The data showed that the A260G SNP is common in the Jordanian population
with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in
the studied population. No significant association was found between the examined
SNPs in DAZL gene and men infertility. Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in
men infertility in Jordanian population.
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Keywords
Deleted in azoospermia-like gene, single nucleotide polymorphism, Jordan, infertility, male
Citation
Khabour Omar F, Al-azzam Akram M, Alfaouri Almuthana A, Zayed Faheem, Sadiq May F. Association of Polymorphisms in DAZL Gene with Male Infertility. British Journal of Medicine and Medical Research. 2013 Jan-Mar; 3(1): 41-48.