MicroRNAs and Their Role in Bone Remodeling and Pathogenesis.
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Date
2012-10
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Abstract
MicroRNAs, a class of post-transcriptional gene expression regulators that bind to
complementary sequences in the 3’ UTR or 5’ UTR of mRNAs have recently been detected
in human body fluids including peripheral blood plasma as extracellular nuclease resistant
entities. It is now clear that the biogenesis and functions of microRNAs are related to the
molecular mechanisms of various clinical diseases and they can potentially regulate every
aspect of cellular activity. This review will highlight our current understanding of microRNA
biogenesis and their mechanisms of action. It will also summarize recent works on the role
of microRNAs in bone remodeling including angiogenesis, osteoblast and osteoclast
differentiation and in various bone related pathologies. An in-depth understanding of the
roles of these regulatory mRNAs in the skeleton will be critical for the development of new
therapeutics aimed on bone remodeling including fracture repair and bone-related
diseases.
Description
Keywords
MicroRNA, biogenesis, expression, bone remodeling, pathogenesis
Citation
Singh Ajai, Ali Sabir, Mahdi Abbas Ali, Nath Srivastava Rajeshwar. MicroRNAs and Their Role in Bone Remodeling and Pathogenesis. British Journal of Medicine and Medical Research. 2012 Oct-Dec; 2(4): 727-749.