Prevalence and Antibiotic Susceptibility Pattern of Methicillin Resistant Staphylococcus aureus in Tertiary Care Hospitals.
Loading...
Date
2014-03
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial
pathogen in hospitals with hospital based outbreaks world-wide. The present study was
carried out to estimate the prevalence of MRSA isolates in clinical specimens and to
investigate the sensitivity pattern of resistant isolates against various antibiotics used for
treating hospitalized patients.
Study Design: The percentage of MRSA was defined as the number of S. aureus
isolates resistant to methicillin divided by the total number of S. aureus isolates for which
methicillin susceptibility test results were reported.
Place and Duration of the Study: The study was conducted during January 2012 to
December 2012 at Asian Hospital (tertiary care hospital), Faridabad, Delhi.
Methodology: A total of 107 isolates of S. aureus were identified by standard laboratory
procedures including catalase test, slide and tube coagulase tests, β- haemolysis on
blood agar and growth on mannitol salt agar. Subsequently, antibiotic sensitivity pattern of
S. aureus were determined by automated antibiotic susceptibility testing system Vitek 2
compact identification and susceptibility testing (ID/AST) system by using AST-GP-67
card.
Result: 23 isolates (21.4%) were identified as MRSA and the remaining 84 (78.6%) were methicillin sensitive S. aureus (MSSA). All MRSA isolates were found to be resistant to
penicillin, oxacillin, ciprofloxacin and levofloxacin. The antibiotic resistance pattern of
these isolates were high against trimethoprim-sulfamethoxazole (91.3%), erythromycin
(47.8%), gentamicin (43.5%), moxifloxacin (42.9%), and less resistance rate was
observed against tetracycline (30.4%) rifampicin (13.6%) and clindamycin (4.8%).
However, all isolates of Staphylococcus were sensitive to vancomycin, linezolid,
nitrofurantoin, quinpristin/daflopristin.
Conclusion: Findings presented in this study indicated a high level of resistance to widely
used therapeutic agents. An appropriate knowledge on the current antibiotic susceptibility
pattern of MRSA is essential for appropriate therapeutic scenario.
Description
Keywords
Staphylococcus aureus, MRSA, prevalence, antibiogram, antibiotics
Citation
N Kaur, R Prasad, Varma A. Prevalence and Antibiotic Susceptibility Pattern of Methicillin Resistant Staphylococcus aureus in Tertiary Care Hospitals. British Biotechnology Journal. 2014 Mar; 4(3): 228-235.