Formulation and evaluation of etoricoxib tablets employing cyclodextrin- poloxamer 407 - PVPK30 inclusion complexes.
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Date
2011-10
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Abstract
Etoricoxib, a widely prescribed anti-inflammatory drug belongs to class IΙ under BCS and
exhibit low and variable oral bioavailability due to its poor aqueous solubility. Its oral absorption is
dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing its
oral bioavailability. The objective of the study is to evaluate the feasibility of formulating etoricoxib – CD
(βCD/ HPβCD) – Poloxamer 407 and etoricoxib – CD (βCD/ HPβCD) –PVP K30 inclusion complexes
into tablets and to evaluate the effects of CDs, Poloxamer 407 and PVP K30 on the dissolution rate of
etoricoxib tablets. A comparative evaluation of wet granulation and direct compression methods was made
for the preparation of tablets employing drug – CD –Poloxamer 407 / PVP K30 inclusion complexes. Drug
– CD- Poloxamer 407 / PVP K30 inclusion complexes were prepared by kneading method. Tablets each
containing 60 mg of etoricoxib were prepared by wet granulation and direct compression methods
employing various CD complexes and the tablets were evaluated for dissolution rate and other physical
properties. toricoxib tablets made by direct compression method disintegrated rapidly when compared to
those made by wet granulation method. Tablets formulated employing βCD complexes disintegrated
relatively more rapidly than those formulated employing HPβCD complexes. Etoricoxib dissolution was
rapid and higher from the tablets formulated employing drug- CD- Poloxamer 407/ PVP K30 inclusion
complexes when compared to the tablets containing etoricoxib alone and drug – CD complexes in both
wet granulation and direct compression methods. In both the methods tablets formulated employing βCD
complexes gave higher dissolution rates (K1) and DE30 values when compared to those formulated
employing HPβCD complexes. Tablets formulated employing dug – βCD – Poloxamer 407 and drug –
βCD – PVP K30 complexes and prepared by direct compression method gave higher dissolution rates,
0.0539 and 0.0459 min-1 respectively when compared to plain tablets (0.0124 min-1 ) as well as tablets
containing drug – βCD complexes (0.0417 min-1). Hence a combination of βCD with Poloxamer 407 or
PVP K30 is recommended to enhance the dissolution rate of etoricoxib tablets.
Description
Keywords
Etoricoxib Tablets, β Cyclodextrin, HP β Cyclodextrin, Poloxamer 407, PVP K30, Dissolution Rate
Citation
Chowdary K P R, Rao K Surya Prakasa, Madhuri D. Formulation and evaluation of etoricoxib tablets employing cyclodextrin- poloxamer 407 - PVPK30 inclusion complexes. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Oct-Dec; 2(4): 43-48.