Comparison of tapentadol with tramadol for analgesia after cardiac surgery.
Loading...
Date
2015-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Tapentadol is a relatively new analgesic. We decided to compare it with tramadol for their various
effects after cardiac surgery. Setting: A study in a tertiary care hospital. Materials and Methods: Sixty adults
undergoing cardiac surgery were divided into 2 groups of 30 each by computerized random allotment
(Group X = tapentadol 50 mg oral and Group Y = tramadol 100 mg oral). Informed Consent and Institutional
Ethics Committee approval were obtained. The patients were given either drug X or drug Y after extubation
in this single blinded study, wherein the data collectors and analyzers were blinded to the study. All patients
received oral paracetamol qds and either drug X or drug Y tds. The pain score was noted on a Visual
Analog Scale before each drug dose, 3 h later and on coughing. Heart rate, respiratory rate, and blood
pressure were recorded before the drug dose and 3 h later. Postoperative nausea or vomiting (PONV),
temperature, and modified Glasgow Coma Scale readings were recorded. The above readings were
obtained for 6 doses (up to 48 h after extubation). Statistics: t‑test, Pearson Chi‑square test, Fisher
exact test, and Mantel–Haenszel test were used for statistics. Results: Tapentadol group patients had
significantly better analgesia 3 h after the drug and “on coughing” than tramadol group. The difference in
their effects on blood creatinine levels, temperature, hemodynamics, oxygen saturation, and respiratory rate
were not clinically significant. Tapentadol produced lesser drowsiness and lesser vomiting than tramadol.
Conclusions: Tapentadol, due to its norepinephrine reuptake inhibition properties, in addition to mu agonist,
is a better analgesic than tramadol and has lesser PONV.
Description
Keywords
Analgesia, Tapentadol, Tramadol
Citation
Iyer Srinivas Kalyanaraman, Mohan Gokulakrishnan, Ramakrishnan Sivakumar, Sanjay Theodore. Comparison of tapentadol with tramadol for analgesia after cardiac surgery. Annals of Cardiac Anaesthesia. 2015 Jul; 18(3): 352-360.