Chitosan–sodium alginate nanocomposites blended with cloisite 30B as a novel drug delivery system for anticancer drug curcumin.
Loading...
Date
2011-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In the present research program, polymer nanocomposites have been used as the
drug carrier for delivery systems of anticancer drug. Chitosan (CS) and sodium alginate (ALG)
with different ratios were blended with different wt% of Cloisite 30B solution by solvent
evaporation method. Cloisite 30B was incorporated in the formulation as a matrix material
component which also plays the role of a co-emulsifier in the nanocomposite preparation.
Curcumin with different concentrations were loaded with CS-ALG/ C 30B nanocomposites for
studying the in-vitro drug delivery systems. Morphology and structure characterization of
nanocomposites were investigated by X-Ray Diffraction (XRD), Scanning Electron Microscope
(SEM) and Fourier Transmission Infra Red Spectroscopy (FTIR) respectively. The drug release
was studied by changing time, pH and drug concentrations. The kinetics of the drug release was
studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the
kinetics, the mechanism of the drug release from the composite matrix has been reported.
Description
Keywords
Chitosan, Sodium alginate, C 30B, Curcumin, Drug delivery
Citation
Malesu Vijay Kumar, Sahoo Debasish, Nayak P L. Chitosan–sodium alginate nanocomposites blended with cloisite 30B as a novel drug delivery system for anticancer drug curcumin. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jul-Sept; 2(3): 402-411.