Zinc-Induced Gastric Ulcer: Case Report on Two Patients with Wilson’s Disease.
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Date
2014-07
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Abstract
Zinc has been developed as an effective and nontoxic therapy in Wilson’s disease. Zinc salts are generally well tolerated. Mild
gastrointestinal discomfort is the major observed side effect and may be dependent on the zinc salt employed. Here, we report two
Wilson’s disease patients who presented with severe gastric ulceration few months after beginning treatment with zinc acetate 50 mg
three times a day. Our patients were not taking any ulcerogenic drugs and had no evidence of Helicobacter pylori infection. In both
patients, zinc acetate was replaced by penicillamine and proton pump inhibitor therapy was initiated with complete resolution of
gastrointestinal symptoms. To our knowledge, this is the first report of zinc acetate-induced gastric ulceration, which should be
looked for in Wilson’s disease patients who develop abdominal discomfort while on this drug.
Description
Keywords
Gastric ulcer, Wilson’s disease, Zinc acetate
Citation
Mirjana Kalauz, Srdjana Telarovic, Dora Grgic, Tomislav Brkic, Katja Grubelic Ravic. Zinc-Induced Gastric Ulcer: Case Report on Two Patients with Wilson’s Disease. Acta Medica International. 2014 Jul-Dec; 1(2): 140-142.