Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells.
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Date
2014-09
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Abstract
Ginseng, one of the most widely used herbal medicines, has a wide range of therapeutic and pharmacological
applications. Ginsenosides are the major bioactive ingredients of ginseng, which are responsible for various pharmacological
activities of ginseng. Ginsenoside Rh2, known as an antitumour ginsenoside, exists as two different
stereoisomeric forms, 20(S)-ginsenoside Rh2 [20(S)-Rh2] and 20(R)-ginsenoside Rh2 [20(R)-Rh2]. This work aimed
to assess and compare skin anti-photoaging activities of 20(S)-Rh2 and 20(R)-Rh2 in UV-B-irradiated HaCat cells.
20(S)-Rh2, but not 20(R)-Rh2, was able to suppress UV-B-induced ROS production in HaCat cells. Both stereoisomeric
forms could not modulate cellular survival and NO level in UV-B-irradiated HaCat cells. Both 20(S)-Rh2 and
20(R)-Rh2 exhibited suppressive effects on UV-B-induced MMP-2 activity and expression in HaCat cells. In brief, the
two stereoisomers of ginsenoside Rh2, 20(S)-Rh2 and 20(R)-Rh2, possess skin anti-photoaging effects but possibly in
different fashions.
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Keywords
Anti-photoaging, ginsenoside Rh2, matrix metalloproteinase, Panax ginseng C.A. Meyer, reactive oxygen species
Citation
Oh Sun-Joo, Lee Sihyeong, Choi Woo-Yong, Lim Chang-Jin. Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells. Journal of Biosciences. 2014 Sep; 39 (4): 673-682.