A comparative study of the effect of ondansetron, granisetron and alprazolam on anxiety in wistar rats.
Loading...
Date
2011-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: The study was undertaken to compare the effect of ondansetron,
granisetron and alprazolam on anxiety in rats.
Materials and Methods: Elevated plus maze and Open field test were used to compare the effect of
drugs on anxiety in rats. Six groups of rats were treated with 2% gum acacia orally, alprazolam
0.08mg/kg body weight of the rat orally, ondansetron (0.01mg/kg, 1mg/kg intraperitoneally) and
granisetron (0.01mg/kg and 1mg/kg intraperitoneally) respectively. The time spent, number of
entries
and rears in the arms of the elevated plus maze and central and peripheral areas in the open field test
Results: Alprazolam and ondansetron significantly increased (P<0.05) the time spent in open arm of
elevated plus maze and central squares in the open field and decreased (P<0.05) the time spent in the
closed arm of elevated maze and peripheral squares in the open field as compared to control. There
was no significant difference between the effects of alprazolam and ondansetron. Granisetron did not
produce any significant effect in any of the models.
Conclusion: Ondansetron, but not granisetron, produced anxiolytic activity in rats which was
comparable to alprazolam.
Description
Keywords
anxiolytic, ondansetron, granisetron, alprazolam, elevated plus maze, open field
Citation
Shenoy Smita, Mohan Lalit, Saravanan, Kumar Shiva, Ramani Anand. A comparative study of the effect of ondansetron, granisetron and alprazolam on anxiety in wistar rats. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jul-Sept; 2(3): 104-108.