Eco friendly synthetic routes for the reduction of carbonyl and the substituted carbonyl compounds.
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Date
2011-04
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Abstract
Incorporation of green methodology via biocatalytic and electrochemical steps using
Baker’s Yeast and electrons as reducing agent respectively have been employed as a novel and efficient
route to furnish relevent chiral building blocks for fine chemicals and pharmaceuticals. Reduction of
selected ketones such as 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone and
ethyl-2-oxocyclopentanecarboxylate have been carried out by biotransformation (using whole cells of
Baker’s Yeast in their free as well as immobilized form in mixtures of glycerol and water) and via
electrochemical method to the corresponding alcohols. Optimum conditions for electrochemical reduction
like solvent, supporting electrolyte, reduction potential and pH were determined at glassy carbon
electrode employing cyclic voltammetric technique. The effect of scan rate, pH were also studied. The
electrochemical reduction was carried out at constant current using stainless steel (SS-316) electrodes.
The products obtained were purified & then the results of both reduction routes (biocatalytic &
electrochemical) were compared and then characterized by spectroscopic techniques.
Description
Keywords
Biocatalysts (Baker’s yeast), cyclic voltammetry (Glassy carbon electrode), constant current electrolysis (SS-316 electrodes), ketones& β- keto esters
Citation
Saharan Ritu, Joshi Jyoti, Verma P S, Sharma I K. Eco friendly synthetic routes for the reduction of carbonyl and the substituted carbonyl compounds. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Apr-June; 2(2): 233-243.