Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
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Date
2012-03
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Abstract
Epidemiological studies have indicated that obesity is associated with colorectal cancer. The obesity hormone leptin
is considered as a key mediator for cancer development and progression. The present study aims to investigate
regulatory effects of leptin on colorectal carcinoma. The expression of leptin and its receptor Ob-R was examined by
immunohistochemistry in 108 Chinese patients with colorectal carcinoma. The results showed that leptin/Ob-R
expression was significantly associated with T stage, TNM stage, lymph node metastasis, distant metastasis,
differentiation and expression of p-mTOR, p-70S6 kinase, and p-Akt. Furthermore, the effects of leptin on
proliferation and apoptosis of HCT-116 colon carcinoma cells were determined. The results showed that leptin could
stimulate the proliferation and inhibit the apoptosis of HCT-116 colon cells through the PI3K/Akt/mTOR pathway.
Ly294002 (a PI3K inhibitor) and rapamycin (an mTOR inhibitor) could prevent the regulatory effects of leptin on the
proliferation and apoptosis of HCT-116 cells via abrogating leptin-mediated PI3K/Akt/mTOR pathway. All these
results indicated that leptin could regulate proliferation and apoptosis of colorectal carcinoma through the PI3K/Akt/
mTOR signalling pathway.
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Keywords
Colorectal carcinoma, HCT-116, leptin, mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase PI3K
Citation
Wang Di, Chen Jian, Chen Hui, Duan Zhi, Xu Qimei, Wei Meiyan, Wang Lianghua, Zhong Meizuo. Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. Journal of Biosciences. 2012 Mar; 37 (1): 91-101.