Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma.
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Date
2011-12
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Abstract
Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this
study was to determine whether an ethanol extract of Polyopes affinis (P.affinis) can inhibit the pathogenesis of T
helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were
sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an
increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory
cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development
of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergenspecific
immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic
extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These
data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic
disorders such as allergic asthma.
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Keywords
Asthma, free radical, IgE, phlorotannins, Polyopes affinis
Citation
Lee Dae-Sung, Park Won Sun, Heo Soo-Jin, Cha Seon-Heui, Kim Daekyung, Jeon You-Jin, Park Sae-Gwang, Seo Su-Kil, Choi Jung Sik, Park Sung-Jae, Shim Eun Bo, Choi Il-Whan, Jung Won-Kyo. Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma. Journal of Biosciences. 2011 Dec; 36 (5): 869-877.