Nucleic acid therapy for lifespan prolongation: Present and future.
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Date
2011-09
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Abstract
Lifespan prolongation is a common desire of the human race. With advances in biotechnology, the mechanism of
aging has been gradually unraveled, laying the theoretical basis of nucleic acid therapy for lifespan prolongation.
Regretfully, clinically applicable interventions do not exist without the efforts of converting theory into action, and it
is the latter that has been far from adequately addressed at the moment. This was demonstrated by a database search
on PubMed and Web of Science, from which only seven studies published between 2000 and 2010 were found to
directly touch on the development of nucleic acid therapy for anti-aging and/or longevity enhancing purposes. In
light of this, the objective of this article is to overview the current understanding of the intimate association between
genes and longevity, and to bring the prospect of nucleic acid therapy for lifespan prolongation to light.
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Keywords
Aging, lifespan, genes, longevity, nucleic acid therapy
Citation
Lai Wing-Fu. Nucleic acid therapy for lifespan prolongation: Present and future. Journal of Biosciences. 2011 Sep; 36 (4): 725-729.