Diuretic effect of chloroform extract of benincasa hispida rind (Pericarp) in sprague-dawley rats.
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Date
2011-04
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Abstract
The diuretic activity of Benincasa hispida fruit rind extract (outer thick pericarp) was
investigated and its activity was compared to control (normal saline) and standard diuretic
hydrochlorothiazide in albino rats. Total of 54 adult male Sprague-Dawley rats were taken whose
weights ranged from 175-225 gm. The rats were divided into three groups of 18 rats each (control,
standard and test). Control group received 0.9% normal saline 25ml/kg orally. Standard group received
hydrochlorothiazide 2.5mg/kg body weight orally along with normal saline keeping the volume of the
fluid administered constant. Test group received aqueous extract of rind of Benincasa hispida at the
dose of 100mg/kg orally along with normal saline 25ml/kg. Urine was collected for a period of 5 hours
by placing the animals in metabolic cages. The urinary volume, pH, and urinary excretion of sodium,
potassium and chloride were measured and compared. The extract produced significant increase
(p<0.001) in urine volume, sodium and chloride levels, and significant decrease (p<0.001) in potassium
excretion. Benincasa hispida rind extract possesses significant diuretic activity.
Description
Keywords
Benincasa hispida, diuretic, urinary volume
Citation
Jayasree T, Kishore K Kiran, Vinay M, Vasavi P, Dixit Rohit, Rajanikanth M, Manohar V S. Diuretic effect of chloroform extract of benincasa hispida rind (Pericarp) in sprague-dawley rats. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Apr-June; 2(2): 94-99.