Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death.
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Date
2011-09
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Abstract
TPC-1 is a highly proliferative thyroid papillary carcinoma-derived cell line. These cells express the RET/PTC1
fusion protein, whose isoforms are characterized in this work. The bacterial alkaloid staurosporine and the plant
extract rotenone are death-inducing drugs that have an inhibitory synergistic effect on the growth of TPC-1 cells. We
show that this synergism is accompanied by an enhancement of the induction of cell death. Staurosporine alone
induces cell cycle arrest in G1, whereas rotenone induces arrest in G2/M. We suggest that this additive pressure may
drive cells to die, resulting in the synergistic interaction of the drug combination. These data emphasize the potential
use of the staurosporine plus rotenone combination as an anticancer tool.
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Keywords
Cell cycle, cell death, RET/PTC1, rotenone, staurosporine, TPC-1
Citation
Goncalves Antonio Pedro, ideira Arnaldo, Maximo Veldemar, Soares Paula. Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. Journal of Biosciences. 2011 Sep; 36 (4): 639-648.