Formulation and evaluation of fast dissolving tablets of granisetron hydrochloride.
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Date
2011-04
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Abstract
Fast dissolving drug delivery systems offers a solution for those patients having difficulty
in swallowing tablets/capsules etc. Granisetron hydrochloride was selected as the model drug. In
the present study, an attempt had been made to prepare fast dissolving tablets of the drug using ,
plantago ovata mucilage and sodium starch glycolate as super disintegrants (2.5 to 10 % w/w)
following by direct compression method. Formulations were evaluated for precompressional
parameters such as angle of repose, carr’s compressibility index and hausner’s ratio. The tablets
were evaluated for uniformity of weight, thickness, hardness, friability, drug content, wetting time,
in-vitro dispersion time and in-vitro dissolution study. The prepared tablets were characterized by
FTIR studies. No chemical interaction between drug and exciepients was confirmed by FTIR
studies.
Description
Keywords
Granisetron hydrochloride, Fast dissolving tablet, Plantago ovata mucilage, Sodium starch glycolate
Citation
Patil Basawaraj S, Rao N G Raghavendra, Rao K Dayakar. Formulation and evaluation of fast dissolving tablets of granisetron hydrochloride. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Apr-June; 2(2): 22-28.