Effect of punica granatum peel extract on burn wound healing in albino wistar rats.
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Date
2011-01
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Abstract
Introduction: Punica granatum is known to have long history of medicinal use. Aqueous
fractions prepared from pomegranate peel extract has been found to stimulate type 1 procollagen synthesis
and inhibit matrix metalloproteinase (which breaks down skin protein) produced by dermal fibroblasts.
Objectives: To study the effect of a topical Punica granatum peel extract on healing of burn wound and to
compare its effect with that of standard (silver sulfadiazine).
Materials and Methods: Partial thickness burn wounds were inflicted upon wistar rats by pouring hot
molten wax at 80˚C in to a metal cylinder with 300mm square circular opening, placed on the back of the
animal. There were four groups in the study viz. control (topical petroleum jelly), standard (topical Silver
Sulphadiazine Cream) and test groups (topical Punica granatum peel extract 10% and 20 %). The
parameters measured were wound contraction and epithelization period in this burn wound model.
Results & Discussion: The percentage of wound contraction was significantly increased in the topical
Punica granatum extract (10% and 20%) and silver sulfadiazine group compared to control group. The
mean period of epithelization was significantly reduced in topical Punica granatum extract (10% and 20%)
group and silver sulfadiazine group as compared to the control.
Conclusion: Punica granatum peel extract is effective in healing burn wound and the effect was
comparable to the standard drug silver sulfadiazine.
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Keywords
Punica granatum, burn wound, epithelization period, wound contraction
Citation
Rajput Ravindrasingh, Sagar V S, Adiga Shalini, Ramyasudha. Effect of punica granatum peel extract on burn wound healing in albino wistar rats. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 353-357.