Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada Roxb.) rhizome.
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Date
2010-06
Authors
Policegoudra, R S
Rehna, K
Rao, L Jaganmohan
Aradhya, S M
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Abstract
Mango ginger (Curcuma amada Roxb.) rhizome is used in the manufacture of pickles and other food preparations
due to its unique raw mango fl avour. The chloroform extract of mango ginger rhizome was subjected to antibacterial
activity-guided purifi cation by repeated silica gel column chromatography to obtain a pure compound. The structure
of the isolated compound was deduced by analysing UV, IR, LC-MS and 2D-HMQCT NMR spectral data, and named
it as amadaldehyde, a novel compound. It exhibited a wide range of antibacterial activity with potential bactericidal
activity against several bacteria. The purifi ed compound also exhibited antioxidant activity, cytotoxicity and platelet
aggregation inhibitory activities.
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Citation
Policegoudra R S, Rehna K, Rao L Jaganmohan, Aradhya S M. Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada Roxb.) rhizome. Journal of Biosciences. 2010 Jun; 35(2): 231-240.