A partner monoclonal antibody to Moab 730 kills 100% of DU145 and PC3 androgen-independent cancer cells.
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Date
2009-12
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Abstract
A number of therapeutic options are available for patients with prostate carcinoma till the time that the tumour is
hormone dependent. However, no fully effective therapy is available for the treatment of androgen-independent
prostate carcinomas. Antibodies directed at epitopes unique to or overexpressed on the cancer cells could be of
therapeutic utility. A monoclonal antibody (Moab) 2C4 has been generated, which binds with cells of two androgenindependent
prostate cancers, DU145 and PC3, and does not bind to peripheral blood leukocytes (PBLs) of healthy
donors. This antibody, along with the previously developed Moab 730, kills 100% of both DU145 and PC3 cells in the
presence of complement and does not have a deleterious effect on PBLs of healthy males. The anti-tumour action of
the two antibodies prevents the establishment of DU145 cell tumour in nude mice in vivo. Moab 2C4 in combination
with 730 has potential for use as therapy for androgen-independent cancers.
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Vyas Hemant Kumar, Pal Rahul, Lohiya Nirmal K, Talwar G P. A partner monoclonal antibody to Moab 730 kills 100% of DU145 and PC3 androgen-independent cancer cells. Journal of Biosciences. 2009 Dec; 34(6): 909-916.