Formulation of mucoadhesive tablet by using aegle marmelos gum.
Loading...
Date
2011-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In the present work, the mucoadhesive tablet of diclofenac (as a model drug) by using
Aegle marmelos fruit gum as a binder was formulated. The preliminary evaluation of Aegle marmelos
gum showed that bulk density 0.42 ± 0.2 g/cm3, tapped density 0.45 ± 0.3 g/cm3 and angle of repose
290 ± 0.15. The six tablet formulation were prepared by using 0.25%, 0.50%, 0.75%, 1%, 1.25% and
1.50% w/w of Aegle marmelos gum by direct compression (F1,F2,F3,F4 and F5 respectively). Tablets
were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity,
swelling behavior, release rate study, mucoadhesive study, and tensile strength study. Formulation was
studied for drug additive interaction (FTIR). F4 is found to be optimized formulation. The in-vitro drug
release of F4 formulation exhibits complete release of Diclofenac Sodium with non fiction first order
release kinetic. The formulation F4 exhibited tensile strength 0.27 N with 10 hrs of mucoadhesion.
From the study it can be conclude that the Aegle marmelos gum used as mucoadhesive sustained
release matrix tablet.
Description
Keywords
Aegle marmelos gum, Mucoadhesive tablets
Citation
Kharwade Rohini S, Vyavhare Neha S, More Sachin M. Formulation of mucoadhesive tablet by using aegle marmelos gum. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 145-153.